How Big Are Microbubbles?
Microbubbles range in size from the nanometer length scale to micrometers. The choice in size has a lot to do with the application. For cell separation, it is important that the microbubbles are in something of a Goldilocks Zone, where they can float with a cell attached but not float too quickly.
At Akadeum, we have chosen a size of microbubble that is specifically fine tuned for cell separation.
In particular, we currently use polydisperse microbubbles that are 16-18 um in diameter. With this size, there is enough buoyant force to easily float cells to the top of a fluid sample. Once the cells are at the top of the fluid, the cell-microbubble complexes can be removed and isolated.