Blog

Published on Feb 12, 2025 Share

Diffuse large B cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin’s lymphoma (NHL), accounting for 30-40% of cases globally. While treatments like chemotherapy, including the R-CHOP regimen, can lead to remission in many patients, relapsed or refractory cases remain challenging, with limited long-term options. CAR T cell therapy transforms the treatment of DLBCL, providing renewed hope to patients by harnessing the body’s immune system to eliminate cancerous cells. …

Published on Feb 10, 2025 Share

B cell acute lymphoblastic leukemia (B-ALL) is an aggressive cancer affecting the bone marrow and blood. When traditional treatments like chemotherapy and radiation fall short in relapsed or refractory cases, CAR T cell therapy provides a transformative new option, offering hope via T cells engineered to target and destroy cancerous B cells. At Akadeum Life Sciences, our innovative cell isolation technologies, including the AlerionTM Microbubble Cell Separation System and our …

Published on Jan 24, 2025 Share

Whether for basic science or advanced applications like CAR T therapy, the efficiency and precision of cell isolation techniques can make or break research outcomes and therapeutic timelines. While magnetic beads have long served as the backbone of T cell isolation, their scalability, speed, and cell health preservation limitations are becoming increasingly apparent. Akadeum Life Sciences’ Alerion™ Microbubble Cell Separation System addresses these challenges with innovative, scalable solutions that integrate …

Published on Jan 10, 2025 Share

Rising cancer rates have been featured heavily in the news this year, especially among younger adults. As cancer rates continue to climb, the need for innovative treatments has never been more pressing. Over recent years, immunotherapy, particularly CAR T cell therapy, emerged as a promising approach, offering renewed hope to patients facing challenging diagnoses through a personalized approach.  However, the increasing demand for these therapies revealed significant bottlenecks in the …

Updated on Feb 17, 2025 Share

Unlocking the Power of Precision Gene Editing for CAR T Cell Therapy Precision is paramount in CAR T cell therapy. As a lab-based cancer treatment technique, CAR T therapy hinges on scientists’ ability to genetically engineer T cells to express receptors that target cancer cells.  T cell populations must be viable and robust enough to undergo gene editing effectively. Therefore, high-quality cell isolation is essential to ensuring CAR T cell …

Updated on Dec 10, 2024 Share

The Role of T Cell Depletion in Optimizing T Cell Recovery As CAR T cell therapies continue to transform cancer treatment, one critical challenge is maximizing the purity and functionality of CAR T cell cultures. T cells are engineered to target and destroy cancer cells in these therapies, making them a powerful option for cancers like leukemia and lymphoma.  However, an essential step in processing CAR T cells in allogeneic …

Updated on Dec 9, 2024 By Jason Ellis, PhD Share

Clonal expansion is the process of rapid cell division resulting in the multiplication of genetically identical cell clones from a single parent cell. In immunology, clonal expansion is a critical process that allows the immune system to produce large numbers of T cells to fight infections. This exponential growth provides a robust concentration of specific genetic material that aids immune and developmental processes. Clonal expansion replaces damaged or worn tissues …

Updated on Nov 18, 2024 Share

T cells, or T lymphocytes, are a critical component of the immune system, with several different types playing unique roles in defending the body. The main types of T cells include helper T cells, cytotoxic T cells, regulatory T cells, and memory T cells, each specialized to recognize and respond to various pathogens. These cells mature in the thymus and are released into the bloodstream as naïve T cells, prepared …

Updated on Dec 3, 2024 Share

When researchers unlock the secrets of T cells, their discoveries often pave the way for groundbreaking advancements in immunotherapy. Antigen-specific T cells, in particular, recognize and neutralize specific threats like pathogens and cancer cells. Their role in targeted immune responses makes them essential in modern immunotherapy and vaccine development. If antigen-specific T cells are crucial for therapies, effectively isolating them may be the key to their success. Emerging Research Applications …

Updated on Dec 10, 2024 Share

Maintaining the health and viability of immune cells in CAR T cell therapy and adoptive cell transfer is critical. These cells must endure isolation and expansion processes without losing their functionality. Even slight inefficiencies can compromise cell integrity and cell health, resulting in diminished therapeutic outcomes. Akadeum’s Alerion™ Microbubble Cell Separation System solves these challenges by offering a gentle, scalable method for T cell separation, ensuring better health and viability. …