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Published on Nov 14, 2024 By Jason Ellis, PhD Share

Clonal expansion is the process of rapid cell division resulting in the multiplication of genetically identical cell clones from a single parent cell. In immunology, clonal expansion is a critical process that allows the immune system to produce large numbers of T cells to fight infections. This exponential growth provides a robust concentration of specific genetic material that aids immune and developmental processes. Clonal expansion replaces damaged or worn tissues …

Updated on Nov 18, 2024 Share

T cells, or T lymphocytes, are a critical component of the immune system, with several different types playing unique roles in defending the body. The main types of T cells include helper T cells, cytotoxic T cells, regulatory T cells, and memory T cells, each specialized to recognize and respond to various pathogens. These cells mature in the thymus and are released into the bloodstream as naïve T cells, prepared …

Published on Nov 6, 2024 Share

When researchers unlock the secrets of T cells, their discoveries often pave the way for groundbreaking advancements in immunotherapy. Antigen-specific T cells, in particular, recognize and neutralize specific threats like pathogens and cancer cells. Their role in targeted immune responses makes them essential in modern immunotherapy and vaccine development. If antigen-specific T cells are crucial for therapies, effectively isolating them may be the key to their success. Emerging Research Applications …

Updated on Nov 5, 2024 Share

Maintaining the health and viability of immune cells in CAR T cell therapy and adoptive cell transfer is critical. These cells must endure isolation and expansion processes without losing their functionality. Even slight inefficiencies can compromise cell integrity and cell health, resulting in diminished therapeutic outcomes. Akadeum’s Alerion™ Microbubble Cell Separation System solves these challenges by offering a gentle, scalable method for T cell separation, ensuring better health and viability. …

Updated on Nov 20, 2024 By Jason Ellis, PhD Share

PBMC isolation separates peripheral blood mononuclear cells from other components in the blood, enabling their use in research and therapeutic applications. Within the human body, a sophisticated network of cells orchestrates the complex immune response against harmful pathogens and cancerous cells. Peripheral blood mononuclear cells (PBMCs), including lymphocytes (T cells, B cells, and NK cells) and monocytes, are vital in mediating the body’s immune system. They are also key starting …

Updated on Nov 15, 2024 Share

Cell dissociation is the process of breaking down tissue or cell culture into individual cells, a critical step in preparing samples for research and therapeutic applications. Different methods of cell dissociation, including enzymatic, mechanical, and chemical techniques, are used to ensure the viability and functionality of cells for further study. Read on to explore the different methods and their importance in advancing scientific research. Cell Dissociation Methods Research is undertaken …

Published on Sep 11, 2024 Share

Antigen-specific T cells offer crucial insights into the body’s immune response to diseases. These specialized cells, which recognize and respond to specific antigens, are essential for: Developing effective vaccines Understanding infectious diseases Advancing cancer immunotherapies In this way, isolating T cells precisely and efficiently is vital for accelerating research and improving therapeutic outcomes. What Are Antigen-Specific T Cells? Antigen-specific T cells are a subset of T cells that recognize and …

Updated on Sep 24, 2024 Share

Cell therapy is transforming medicine, offering new hope for patients with previously untreatable conditions. Imagine a world where damaged tissues can be repaired, immune systems recalibrated, and cancer targeted with precision—this is the promise of cell therapy. What Is Cell Therapy? Cell therapy involves administering live cells to a patient to repair or replace damaged tissues and cells. This approach leverages the body’s cellular machinery to combat diseases. The cells …

Updated on Sep 4, 2024 Share

Necrosis and apoptosis are the two main types of cell death in the body. Necrosis is often a result of injury leading to uncontrolled cell death, while apoptosis is a programmed and orderly process. Each of these involves a unique process and has different effects on the rest of the body. Understanding these differences is crucial for researchers and clinicians in developing treatments for various diseases. Read on to delve …

Updated on Nov 20, 2024 Share

Peripheral Blood Mononuclear Cells Peripheral blood mononuclear cells (PBMC) are crucial immune system cells that protect the body against harmful pathogens. Human PBMCs include T cells, B cells, NK cells, monocytes, and dendritic cells. These cells are essential in immune response and are often used in research and clinical applications due to their versatility. Located in peripheral blood, these cells act as a primary defense against infection and disease, making …