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Published on Jan 10, 2025 Share

Rising cancer rates have been featured heavily in the news this year, especially among younger adults. As cancer rates continue to climb, the need for innovative treatments has never been more pressing. Over recent years, immunotherapy, particularly CAR T cell therapy, emerged as a promising approach, offering renewed hope to patients facing challenging diagnoses through a personalized approach.  However, the increasing demand for these therapies revealed significant bottlenecks in the …

Updated on Dec 23, 2024 Share

Unlocking the Power of Precision Gene Editing for CAR T Cell Therapy Precision is paramount in CAR T cell therapy. As a lab-based cancer treatment technique, CAR T therapy hinges on scientists’ ability to genetically engineer T cells to express receptors that target cancer cells.  T cell populations must be viable and robust enough to undergo gene editing effectively. Therefore, high-quality cell isolation is essential to ensuring CAR T cell …

Updated on Dec 10, 2024 Share

The Role of T Cell Depletion in Optimizing T Cell Recovery As CAR T cell therapies continue to transform cancer treatment, one critical challenge is maximizing the purity and functionality of CAR T cell cultures. T cells are engineered to target and destroy cancer cells in these therapies, making them a powerful option for cancers like leukemia and lymphoma.  However, an essential step in processing CAR T cells in allogeneic …

Updated on Dec 9, 2024 By Jason Ellis, PhD Share

Clonal expansion is the process of rapid cell division resulting in the multiplication of genetically identical cell clones from a single parent cell. In immunology, clonal expansion is a critical process that allows the immune system to produce large numbers of T cells to fight infections. This exponential growth provides a robust concentration of specific genetic material that aids immune and developmental processes. Clonal expansion replaces damaged or worn tissues …

Updated on Nov 18, 2024 Share

T cells, or T lymphocytes, are a critical component of the immune system, with several different types playing unique roles in defending the body. The main types of T cells include helper T cells, cytotoxic T cells, regulatory T cells, and memory T cells, each specialized to recognize and respond to various pathogens. These cells mature in the thymus and are released into the bloodstream as naïve T cells, prepared …

Updated on Dec 3, 2024 Share

When researchers unlock the secrets of T cells, their discoveries often pave the way for groundbreaking advancements in immunotherapy. Antigen-specific T cells, in particular, recognize and neutralize specific threats like pathogens and cancer cells. Their role in targeted immune responses makes them essential in modern immunotherapy and vaccine development. If antigen-specific T cells are crucial for therapies, effectively isolating them may be the key to their success. Emerging Research Applications …

Updated on Dec 10, 2024 Share

Maintaining the health and viability of immune cells in CAR T cell therapy and adoptive cell transfer is critical. These cells must endure isolation and expansion processes without losing their functionality. Even slight inefficiencies can compromise cell integrity and cell health, resulting in diminished therapeutic outcomes. Akadeum’s Alerion™ Microbubble Cell Separation System solves these challenges by offering a gentle, scalable method for T cell separation, ensuring better health and viability. …

Updated on Dec 3, 2024 By Jason Ellis, PhD Share

PBMC isolation separates peripheral blood mononuclear cells from other components in the blood, enabling their use in research and therapeutic applications. Within the human body, a sophisticated network of cells orchestrates the complex immune response against harmful pathogens and cancerous cells. Peripheral blood mononuclear cells (PBMCs), including lymphocytes (T cells, B cells, and NK cells) and monocytes, are vital in mediating the body’s immune system. They are also key starting …

Updated on Nov 21, 2024 Share

Cell dissociation is the process of breaking down tissue or cell culture into individual cells, a critical step in preparing samples for research and therapeutic applications. Different methods of cell dissociation, including enzymatic, mechanical, and chemical techniques, are used to ensure the viability and functionality of cells for further study. Read on to explore the different methods and their importance in advancing scientific research. Cell Dissociation Methods Research is undertaken …

Updated on Dec 9, 2024 Share

Antigen-specific T cells offer crucial insights into the body’s immune response to diseases. These specialized cells, which recognize and respond to specific antigens, are essential for: Developing effective vaccines Understanding infectious diseases Advancing cancer immunotherapies In this way, isolating T cells precisely and efficiently is vital for accelerating research and improving therapeutic outcomes. What Are Antigen-Specific T Cells? Antigen-specific T cells are a subset of T cells that recognize and …