Microbubbles for Cell Sorting and Sample Purification

Welcome to our blog. We are excited about microbubbles and using them for cell sorting. In this blog, we will discuss:

  • The features of microbubbles that make them a powerful tool in sorting cell and other biological targets
  • The background and basis of buoyancy-activated cell sorting (BACS™)
  • Various micrbubble applications, ranging from red blood cell removal to food pathogen preconentration (yes microbubbles can be used for both)
  • Technical perspectives from physics to biology

At Akadeum we care deeply about making meaningful products and having conversations with our customers. With this in mind, email us with any topic request, questions, or even if you are interested in a guest post.


The Physics of How Microbubbles Sort Cells

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I’m going to devote this first post to floatation, which is the driving principle behind our cell sorting technology. It’s hard to imagine many other physical phenomena that humans have more of an intuition for than floating and sinking. The exact same rules of floating and sinking apply to a stem cell being lifted from a sample on the back of an Akadeum microbubble. In principal, it is as simple as pair of water wings that keeps a 2 year old afloat. Understanding these rules lets you anticipate important performance features of separation systems like ours. It allows for questions to be answered like How long will it take for my cells to get to the top of the tube? (Not long) Can microbubbles lift a spheroid? (Probably) How many microbubbles do you need to float a large cell? (One) The answer to these questions may have a big impact on the success of your cell...

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