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Primary T Cell Culture and Expansion

Updated on Jan 3, 2025 By Dominique Badea, PhD

Microscopic View of T Cells

T Cells are a critical component of the immune system. They play a pivotal role in the body’s defense against infections, cancer, and a variety of other diseases. To harness the full potential of these immune warriors, scientists have worked hard on perfecting the art of T cell culturing. Research and development of new immunotherapies requires robust techniques to purify and culture T cells. This article serves as a primer …

T Cell Immune Response and Cytokine Storm in COVID-19 Patients

Updated on Dec 9, 2024

COVID-19

T Cells and COVID-19 The body is naturally equipped with a variety of T lymphocytes that work together to fend off harmful pathogens. The human immune system routinely battles mild diseases with recognizable antigens. By attacking the source of a virus or bacteria, damage to healthy cells can be minimized. The T cell immune response to COVID-19 is different because it’s caused by an RNA virus (SARS-CoV-2). RNA viruses insert …

The Role of B Cells and T Cells in COVID-19 Immune Response & T Cell Immunity in COVID-19 Patients

Updated on Aug 17, 2023

Recent developments in COVID-19 immunology research look at the role T cells and B cells play in immune response to infection with SARS-CoV-2. The global scientific community has made great strides in characterizing the immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). There are several studies that have been published in recent months that take a closer look at how …

Akadeum Microbubbles: The Novel Approach to COVID Research (Webinar Dec 16)

Updated on Sep 13, 2023

The emergence of COVID-19 has changed life as we know it the world over. This is a fast-moving and deadly pandemic that requires novel, next-generation technology to enable ongoing research and advanced diagnostic testing. Join us on December 16 to get an inside look at how Akadeum’s products and cell separation technology are contributing to the solutions of tomorrow. In this webinar, we will cover:  An overview of the microbubble …

Improving Cell Separation for Single Cell RNA Sequencing

Updated on Dec 9, 2024

Scientist in a lab

RNA-Sequencing Medical advancements have provided researchers with strategies that change the way in which we understand biology. Scientists are now capable of studying coded protein patterns at a genomic level. RNA-sequencing (RNA-seq) is the process of detecting and analyzing the messenger RNA (mRNA) of a cell type. The range of mRNA molecules present in an organism is also known as the transcriptome. Identifying a biological transcriptome can give a better …

TIL Therapy: Revolutionizing Solid Tumor Treatment

Updated on Nov 20, 2024

Tumor-infiltrating lymphocyte (TIL) therapy is a modern cancer treatment used to combat notoriously hard-to-treat solid tumors. Like other adoptive cell therapies, TIL harnesses the body’s immune system to combat malignancies by using T cells, a type of white blood cell integral to immune response. Except in TIL therapy, these T cells are directly extracted from tumors. Having survived the tumor microenvironment, these lymphocytes are already primed to recognize and attack …

TCR Vs. CAR T: What is CAR T Cell, TCR Therapy, and What are They Used For?

Updated on Jan 17, 2025 By Jason Ellis, PhD

Researchers and clinicians constantly adapt medical research and cancer treatment to overcome new challenges. When more traditional methods fail to fend off certain malignancies, patients can now turn to adoptive cell therapy as a new treatment option. Adoptive cell therapy involves the combination of human T cells with scientific enhancements to treat diseases the body isn’t adequately equipped to handle on its own. Introducing Next-Gen Cell Separation With Akadeum’s Microbubbles: …

CAR T Cells: How These Cancer Fighting T Cells are Harvested and Manufactured for Immunotherapy

Updated on Dec 10, 2024

T cell lymphocytes

Immunotherapy Immunology is the study of the immune system and what it can do, immunotherapy is the study of how to do things the immune system can’t do. In immunotherapy, researchers observe and manipulate T cells in the body in an effort to make up for humans’ natural deficiencies. There are multiple methods of immunotherapy — each for different purposes. While some strategies merely extract T cells for a population …

What is Protein Therapy and What Role Does Cell Separation Play in it?

Updated on Sep 27, 2024

Proteins are large molecules in the body that play a critical role in virtually everything that happens. Movement, maturation, and other processes are not possible without a lot of proteins. Protein therapy is a form of treatment that involves sending in well-structured proteins to a precise target location to repair or replace damaged ones. This is one of the most widely used treatment methods due to its accuracy and lack …

How Sample Viability Is Affected by Cell Loss

Updated on Dec 9, 2024

Cell Loss in Separation and Isolation Assays When performing research, it’s easy to forget that individual cells are living things. Each one has its own role and internal organelles that help it survive from day-to-day. The process of isolating cells for research and removing them from their ideal environment can be harmful. Significance With each lost cell the sample becomes less valuable. Often, the goal of isolating cells is to …

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