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Updated on Dec 9, 2024 Share

RNA-Sequencing Medical advancements have provided researchers with strategies that change the way in which we understand biology. Scientists are now capable of studying coded protein patterns at a genomic level. RNA-sequencing (RNA-seq) is the process of detecting and analyzing the messenger RNA (mRNA) of a cell type. The range of mRNA molecules present in an organism is also known as the transcriptome. Identifying a biological transcriptome can give a better …

Updated on Nov 20, 2024 Share

Tumor-infiltrating lymphocyte (TIL) therapy is a modern cancer treatment used to combat notoriously hard-to-treat solid tumors. Like other adoptive cell therapies, TIL harnesses the body’s immune system to combat malignancies by using T cells, a type of white blood cell integral to immune response. Except in TIL therapy, these T cells are directly extracted from tumors. Having survived the tumor microenvironment, these lymphocytes are already primed to recognize and attack …

Updated on Dec 2, 2024 By Jason Ellis, PhD Share

Researchers and clinicians constantly adapt medical research and cancer treatment to overcome new challenges. When more traditional methods fail to fend off certain malignancies, patients can now turn to adoptive cell therapy as a new treatment option. Adoptive cell therapy involves the combination of human T cells with scientific enhancements to treat diseases the body isn’t adequately equipped to handle on its own. Introducing Next-Gen Cell Separation With Akadeum’s Microbubbles: …

Updated on Dec 10, 2024 Share

Immunotherapy Immunology is the study of the immune system and what it can do, immunotherapy is the study of how to do things the immune system can’t do. In immunotherapy, researchers observe and manipulate T cells in the body in an effort to make up for humans’ natural deficiencies. There are multiple methods of immunotherapy — each for different purposes. While some strategies merely extract T cells for a population …

Updated on Sep 27, 2024 Share

Proteins are large molecules in the body that play a critical role in virtually everything that happens. Movement, maturation, and other processes are not possible without a lot of proteins. Protein therapy is a form of treatment that involves sending in well-structured proteins to a precise target location to repair or replace damaged ones. This is one of the most widely used treatment methods due to its accuracy and lack …

Updated on Dec 9, 2024 Share

Cell Loss in Separation and Isolation Assays When performing research, it’s easy to forget that individual cells are living things. Each one has its own role and internal organelles that help it survive from day-to-day. The process of isolating cells for research and removing them from their ideal environment can be harmful. Significance With each lost cell the sample becomes less valuable. Often, the goal of isolating cells is to …

Updated on Dec 4, 2024 Share

Adoptive Immunotherapy The human body is naturally equipped with tools to fight off infectious diseases and harmful pathogens. An intricate system of cells works together to facilitate an immune response that defends the body from dangerous substances. Although this process is both fast and adaptive, there are limitations to what it can do. Certain diseases, such as cancer, can intensify to a point where the immune system is no longer …

Updated on Mar 10, 2022 Share

Early Data from Akadeum’s RNA Extraction Project for Pooled Saliva Samples   Current COVID-19 saliva testing is limited. Akadeum’s microbubbles aim to change everything. At Akadeum Life Sciences, we are actively working to develop an innovative cell separation approach that makes pooled saliva testing possible – in an accurate and cost-effective way. We have expanded our microbubble platform by functionalizing our revolutionary buoyancy-activated separation (BACS™) technology for RNA isolation in …

Updated on Aug 21, 2023 Share

T Cell Receptors T Cell Receptors (TCRs) are protein complexes found on the surface of T cells or T lymphocytes responsible for recognizing antigens on foreign substances. Without TCRs, the immune system would not be able to successfully identify and fight infectious disease. Structure of TCRs T cell receptors are members of the immunoglobulin family; a large group of proteins responsible for binding to and recognizing antibodies. Within the chains …

Updated on Nov 28, 2023 Share

Optimizing a cell separation method is critical for many researchers. There are various ways to sort different types of cells, and the best methodology often depends on the cell subset. One of the quicker and more cost-effective ways to sort a sample based only on physical characteristics is using centrifugation.